Abstract #0056

Evaluating pCR after neoadjuvant systemic treatment of invasive breast cancer using DWI in comparison to DCE-based kinetic analysis

Rie Ota¹, Masako Kataoka¹, Maya Honda¹, Mami Iima¹, Kanae Kwai Miyake¹, Akane Ohashi², Yosuke Yamada³, Masakazu Toi⁴, and Yuji Nakamoto¹

¹Department of Diagnostic Imaging and Nuclear Medicine, Kyoto University graduate school of medicine, Kyoto, Japan, ²Kyoto Medical Center, Kyoto, Japan, ³Department of Pathology, Kyoto University Hospital, Kyoto, Japan, ⁴Department of Breast Surgery, Kyoto University Hospital, Kyoto, Japan

This study aimed to examine the performance of DWI in diagnosing pCR before surgery. Kinetic analysis from standard DCE-MRI were analyzed for comparison. ROC analysis for diagnosing pCR based on DWI score/Kinetic score by two readers was performed. Kinetic score showed slightly higher AUC while 95% confidence interval overlapped with that of DWI score. Both kinetic score and DWI score demonstrated excellent diagnostic performance among triple negative subtype compared to other subtypes.

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