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Abstract #0056

Evaluating pCR after neoadjuvant systemic treatment of invasive breast cancer using DWI in comparison to DCE-based kinetic analysis

Rie Ota1, Masako Kataoka1, Maya Honda1, Mami Iima1, Kanae Kwai Miyake1, Akane Ohashi2, Yosuke Yamada3, Masakazu Toi4, and Yuji Nakamoto1
1Department of Diagnostic Imaging and Nuclear Medicine, Kyoto University graduate school of medicine, Kyoto, Japan, 2Kyoto Medical Center, Kyoto, Japan, 3Department of Pathology, Kyoto University Hospital, Kyoto, Japan, 4Department of Breast Surgery, Kyoto University Hospital, Kyoto, Japan

This study aimed to examine the performance of DWI in diagnosing pCR before surgery. Kinetic analysis from standard DCE-MRI were analyzed for comparison. ROC analysis for diagnosing pCR based on DWI score/Kinetic score by two readers was performed. Kinetic score showed slightly higher AUC while 95% confidence interval overlapped with that of DWI score. Both kinetic score and DWI score demonstrated excellent diagnostic performance among triple negative subtype compared to other subtypes.

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