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Abstract #0057

Multiparametric MRI signatures of immune response in patients with HER2+ breast cancer treated with trastuzumab

Bonny Chau1, Debosmita Biswas1, Anum S. Kazerouni1, Daniel S. Hippe1, Rebeca Alvarez1, Suzanne Dintzis1, Laura C. Kennedy2, Vijayakrishna Gadi3, and Savannah C. Partridge 1
1University of Washington, Seattle, WA, United States, 2Vanderbilt University, Nashville, TN, United States, 3University of Illinois, Chicago, IL, United States

We investigated the relationship between immune infiltration and imaging metrics derived from breast MRI in patients with HER2+ breast cancer treated with trastuzumab. Fourteen patients with localized HER2+ breast cancer were imaged with diffusion-weighted and dynamic contrast-enhanced (DCE-) MRI prior to and ~2 weeks after a run-in dose of trastuzumab. Pre-treatment ADC and change in DCE-MRI peak percent enhancement were both significantly associated with immune response as characterized by change in level of tumor infiltrating lymphocytes.

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