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Abstract #0074

DTI and gluCEST imaging reveal the key role of white matter alteration in the pathogenesis in a mouse model of Huntington’s Disease

Jean-Baptiste Perot1, Marina Célestine1, Marc Dhenain1, Sandrine Humbert2, Emmanuel Brouillet1, and Julien Flament1
1Université Paris-Saclay, Commissariat à l’Energie Atomique et aux Energies Alternatives (CEA), Centre National de la Recherche Scientifique (CNRS), Molecular Imaging Research Center (MIRCen), Laboratoire des Maladies Neurodégénératives, Fontenay-aux-Roses, France, 2Université Grenoble-Alpes, Grenoble Institute of Neurosciences (GIN), INSERM U1216, Grenoble, France

Huntington’s Disease (HD) is a neurodegenerative disorder caused by the expansion of CAG repeats on the exon 1 of the HTT gene. Although genetic origin of HD is well-established, early and predictive biomarkers of disease onset and progression are still lacking. In the present study, we performed a multiparametric longitudinal MRI study on a mouse model of HD. Our results in gluCEST, Magnetization Transfer, morphometry and Diffusion Tensor Imaging revealed early modifications of white matter followed by progressive functional and anatomical changes in HD mice. Such network seems to point out the central role of white matter in HD pathogenesis.

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