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Abstract #0075

Multimodal MRI study of multiple sclerosis: the therapeutic role of complement system  

Abdullah Althobity1,2, Nemat Khan3, Trent Woodruff3, Gary Cowin1,4, Ian Brereton1,4, and Nyoman Kurniawan1
1Centre for Advanced imaging, University of Queensland, Brisbane, Australia, 2Ministry of Education, Riyadh, Saudi Arabia, 3Faculty of Medicine, School of Biomedical Sciences, University of Queensland, Brisbane, Australia, 4National Imaging Facility, Brisbane, Australia

Multiple sclerosis (MS) is an autoimmune disease with uncertain aetiology. In this work, we used two genetically modified mice, each derived by gene ablation to complement protein C5aR1 and C5L2 receptors, designed to investigate their roles in mediating the disease model experimental autoimmune encephalomyelitis (EAE). MR spectroscopy and DTI were measured using a 9.4T MRI with cryoprobe at the level of lumbar spinal cord. Changes in metabolites and DTI parameters indicate that the ablation of C5L2, to a greater extent than the ablation of C5aR1, made these mice less susceptible to EAE induced neuronal damage compared to wild-type mice.

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