Abstract #0079

A Mn-based probe targeted towards organic-anion transporting polypeptides

Nivin N Nyström¹, Hanlin Liu², Francisco Martínez-Santiesteban¹, Xiao-an Zhang², Timothy J Scholl¹, and John A Ronald¹

¹Robarts Research Institute, London, ON, Canada, ²University of Toronto, Toronto, ON, Canada

We have developed a manganese(III) porphyrin probe for targeted imaging of cells expressing organic-anion transporting polypeptides. OATP1 targeting and relaxation characteristics were evaluated in vitro in engineered cells, and in vivo and ex vivo in different organs in mice.

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