Abstract #0080

MR Measurements of Placental Perfusion in Normal Sheep Pregnancies

Dimitra Flouri^1,2, Jack RT Darby³, Stacey L Holman³, Sunthara R Perumal⁴, Anna L David^5,6, Janna L Morrison³, and Andrew Melbourne^2,7

¹School of Biomedical Engineering & Imaging Sciences, King's College London, London, United Kingdom, ²Department of Medical Physics & Biomedical Engineering, University College London, London, United Kingdom, ³Early Origins of Adult Health Research Group, University of South Australia, Adelaide, Australia, ⁴Preclinical Imaging and Research Laboratories, South Australian Health and Medical Research Institute, Adelaide, Australia, ⁵Elizabeth Garrett Anderson Institute for Women’s Health, University College London, London, United Kingdom, ⁶NIHR Biomedical Research Centre, University College London Hospitals, London, United Kingdom, ⁷School of Biomedical Engineering and Imaging Sciences, King's College London, London, United Kingdom

MRI techniques are considered to give additional placental information in vivo to support clinical decision-making. Preclinical models such as in pregnant sheep provide an invasive method to validate MRI measurements, as they allow for controlled experiments and analysis during pregnancy. Here we characterised diffusion and perfusion properties of normal sheep placenta such as apparent diffusion coefficient, T2 measurements and fractional anisotropy analysis. We also presented the first application of multi-compartment MRI model to normal sheep placenta.

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