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Abstract #0080

MR Measurements of Placental Perfusion in Normal Sheep Pregnancies 

Dimitra Flouri1,2, Jack RT Darby3, Stacey L Holman3, Sunthara R Perumal4, Anna L David5,6, Janna L Morrison3, and Andrew Melbourne2,7
1School of Biomedical Engineering & Imaging Sciences, King's College London, London, United Kingdom, 2Department of Medical Physics & Biomedical Engineering, University College London, London, United Kingdom, 3Early Origins of Adult Health Research Group, University of South Australia, Adelaide, Australia, 4Preclinical Imaging and Research Laboratories, South Australian Health and Medical Research Institute, Adelaide, Australia, 5Elizabeth Garrett Anderson Institute for Women’s Health, University College London, London, United Kingdom, 6NIHR Biomedical Research Centre, University College London Hospitals, London, United Kingdom, 7School of Biomedical Engineering and Imaging Sciences, King's College London, London, United Kingdom

MRI techniques are considered to give additional placental information in vivo to support clinical decision-making. Preclinical models such as in pregnant sheep provide an invasive method to validate MRI measurements, as they allow for controlled experiments and analysis during pregnancy. Here we characterised diffusion and perfusion properties of normal sheep placenta such as apparent diffusion coefficient, T2 measurements and fractional anisotropy analysis. We also presented the first application of multi-compartment MRI model to normal sheep placenta.

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