Meeting Banner
Abstract #0088

Diffuse axonal injury has a specific multidimensional MRI signature in traumatically injured corpus callosum

Dan Benjamini1, Diego Iacono2, Michal Komlosh1, Daniel Perl2, David Brody2, and Peter Basser1
1National Institute of Child Health and Human Development, Bethesda, MD, United States, 2Uniformed Services University of the Health Sciences, Bethesda, MD, United States

Can microscopic diffuse axonal injury lesions following trauma be seen non-invasively? We report that simultaneously integrating multiple MRI dimensions - T1, T2, and diffusion - can be targeted to image microscopic damage. Corpora Callosa derived from eight subjects that sustained TBI and three healthy control brain donors underwent post-mortem ex-vivo MRI at 7T. Multidimensional-, diffusion tensor-, and quantitative T1- and T2-MRI data were acquired and processed, along with corresponding pathohistological data. Although invisible using the conventional MRI modalities, multidimensional MRI provided images of the microscopic injuries, suggesting that it can be used for the detection of microscopic axonal injury.

This abstract and the presentation materials are available to members only; a login is required.

Join Here