Can microscopic diffuse axonal injury lesions following trauma be seen non-invasively? We report that simultaneously integrating multiple MRI dimensions - T1, T2, and diffusion - can be targeted to image microscopic damage. Corpora Callosa derived from eight subjects that sustained TBI and three healthy control brain donors underwent post-mortem ex-vivo MRI at 7T. Multidimensional-, diffusion tensor-, and quantitative T1- and T2-MRI data were acquired and processed, along with corresponding pathohistological data. Although invisible using the conventional MRI modalities, multidimensional MRI provided images of the microscopic injuries, suggesting that it can be used for the detection of microscopic axonal injury.
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