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Abstract #0087

High temporospatial resolution MR imaging of neuronal activity in vivo

Phan Tan Toi1,2,3, Hyun Jae Jang4, Jeehyun Kwag4, and Jang-Yeon Park1,2,3
1Department of Biomedical Engineering, Sungkyunkwan University, Suwon, Korea, Republic of, 2Center for Neuroscience Imaging Research, Institute for Basic Science, Suwon, Korea, Republic of, 3Department of Intelligent Precision Healthcare Convergence, Sungkyunkwan University, Suwon, Korea, Republic of, 4Department of Brain and Cognitive Engineering, Korea University, Seoul, Korea, Republic of

Advanced non-invasive functional imaging methods have been widely used, but with certain limitations in either temporal or spatial information. There has long been a demand for a noninvasive imaging method capable of capturing neuronal activity with high temporal and spatial resolution. Here, we demonstrate a novel imaging method (called DIANA-fMRI) for directly detecting neuronal activity with high temporal (=5ms) and spatial (=0.22mm) resolution. DIANA-fMRI was capable of capturing sensory responses in mice at 9.4T with statistically significant signal changes (~0.1-0.2%). Temporally sequential DIANA responses were also confirmed along the thalamocortical pathway, together with further validation by electrophysiological experiments.

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