Abstract #0086

Noninvasive Detection of Changes in Membrane Potential with MR Measurements

Kyeongseon Min¹, Sungkwon Chung², Phan Tan Toi^3,4, Jongho Lee¹, Seung‐Kyun Lee^3,4,5, and Jang-Yeon Park^3,4

¹Laboratory for Imaging Science and Technology, Department of Electrical and Computer Engineering, Seoul National Univeristy, Seoul, Korea, Republic of, ²Department of Physiology, Samsung Biomedical Research Institute, Sungkyunkwan University School of Medicine, Suwon, Korea, Republic of, ³Department of Biomedical Engineering, Sungkyunkwan University, Suwon, Korea, Republic of, ⁴Department of Intelligent Precision Healthcare Convergence, Sungkyunkwan University, Suwon, Korea, Republic of, ⁵Center for Neuroscience Imaging Research, Institute for Basic Science, Suwon, Korea, Republic of

In this study, the relationships between changes in cell membrane potential and MR measurements of T₁, T₂, and qMT parameters were examined using a neuroblastoma cell line (SH-SY5Y) as an in vitro model. When the membrane potential was depolarized from -37.7 mV to −7.5 mV, the changes in MR parameters were: T₁, +4.29%; T₂, +21.2%; pool size ratio (PSR), −12.4%. Contrarily, when the membrane potential was hyperpolarized to −43.0 mV, the changes in MR parameters were: T₁, −3.40%; T₂, −10.0%; PSR, +6.97%. These observations are expected to be utilized to noninvasively detect changes in the membrane potential of cells.

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