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Abstract #0086

Noninvasive Detection of Changes in Membrane Potential with MR Measurements

Kyeongseon Min1, Sungkwon Chung2, Phan Tan Toi3,4, Jongho Lee1, Seung‐Kyun Lee3,4,5, and Jang-Yeon Park3,4
1Laboratory for Imaging Science and Technology, Department of Electrical and Computer Engineering, Seoul National Univeristy, Seoul, Korea, Republic of, 2Department of Physiology, Samsung Biomedical Research Institute, Sungkyunkwan University School of Medicine, Suwon, Korea, Republic of, 3Department of Biomedical Engineering, Sungkyunkwan University, Suwon, Korea, Republic of, 4Department of Intelligent Precision Healthcare Convergence, Sungkyunkwan University, Suwon, Korea, Republic of, 5Center for Neuroscience Imaging Research, Institute for Basic Science, Suwon, Korea, Republic of

In this study, the relationships between changes in cell membrane potential and MR measurements of T1, T2, and qMT parameters were examined using a neuroblastoma cell line (SH-SY5Y) as an in vitro model. When the membrane potential was depolarized from -37.7 mV to −7.5 mV, the changes in MR parameters were: T1, +4.29%; T2, +21.2%; pool size ratio (PSR), −12.4%. Contrarily, when the membrane potential was hyperpolarized to −43.0 mV, the changes in MR parameters were: T1, −3.40%; T2, −10.0%; PSR, +6.97%. These observations are expected to be utilized to noninvasively detect changes in the membrane potential of cells.

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