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Abstract #0085

Improved spin-lock based detection of ultra-low-field electro-magnetic oscillations for direct fMRI

Maximilian Gram1,2, Markus Dippold2, Daniel Gensler1,3, Martin Blaimer4, Peter Nordbeck1,3, and Peter Michael Jakob2
1Department of Internal Medicine I, University Hospital Würzburg, Würzburg, Germany, 2Experimental Physics 5, University of Würzburg, Würzburg, Germany, 3Comprehensive Heart Failure Center (CHFC), University Hospital Würzburg, Würzburg, Germany, 4Fraunhofer Institute for Integrated Circuits IIS, Würzburg, Germany

BOLD-based fMRI is currently the method of choice for the spatially resolved investigation of neuronal activity, although this technique only allows indirect measurements of activity by evaluating hemodynamic effects. Recently, a spin-lock-based technique for the direct measurement of neuro-electro-magnetic oscillations was presented, which impressively demonstrated imaging of the alpha activity. In the corresponding publication, however, elementary parameters of the spin-lock preparation were specified ad hoc. In the present work it is shown that the choice of these preparation parameters is of essential importance. For example, a clever choice of the spin-lock time can improve and stabilize the signal detection.

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