The main iron compounds, ferritin and transferrin, are distributed heterogeneously across the brain and are often implicated in neurodegenerative diseases. While quantitative MRI has been linked to brain tissue’s microstructure, non-invasive discrimination between iron forms still remains a challenge. We propose an in vivo approach for assessing brain iron forms, based on the dependency of R1 on R2*. We establish this approach in phantoms and validate it against histology. In the in vivo human brain, the dependency of R1 on R2*, rather than each parameter by itself, predicts the inhomogeneous distribution of iron-binding proteins with age and across brain regions.
How to access this content:
For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.
After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.
After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.
Keywords