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Abstract #0083

Comparison of inhomogeneous Magnetization Transfer (ihMT), R1 and MPF for myelin specific imaging

Andreea Hertanu1,2, Lucas Soustelle1,2, Arnaud Le Troter1,2, Julie Buron1,2,3, Julie Le Priellec3, Myriam Cayre3, Pascale Durbec3, Gopal Varma4, David C. Alsop4, Olivier M. Girard1,2, and Guillaume Duhamel1,2
1Aix Marseille Univ, CNRS, CRMBM, Marseille, France, 2APHM, Hôpital Universitaire Timone, CEMEREM, Marseille, France, 3Aix Marseille Univ, CNRS, IBDM, Marseille, France, 4Division of MR Research, Radiology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, United States

We conducted a comparative study of ihMT metrics variably weighted in T1D, with R1 (1/T1) and MPF (macromolecular proton fraction) for myelin specific imaging. These MRI methods were compared with histology by fluorescence microscopy using transgenic plp-GFP (proteolipid protein-Green Fluorescent Protein) mice.

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