Abstract #0094

On Comparability and Reproducibility of Myelin Sensitive Imaging Techniques

Tom Hilbert^1,2,3, Lucas Soustelle⁴, Gian Franco Piredda^1,2,3, Thomas Troalen⁵, Stefan Sommer^6,7, Arun Joseph^8,9,10, Reto Meuli², Jean-Philippe Thiran^2,3, Guillaume Duhamel⁴, Olivier M. Girard⁴, and Tobias Kober^1,2,3

¹Advanced Clinical Imaging Technology (ACIT), Siemens Healthcare, Lausanne, Switzerland, ²Department of Radiology, Lausanne University Hospital (CHUV), Lausanne, Switzerland, ³LTS5, École Polytechnique Fédérale de Lausanne, Lausanne, Switzerland, ⁴Aix Marseille Univ, CNRS, CRMBM, Marseille, France, ⁵Siemens Healthcare SAS, Saint-Denis, France, ⁶Siemens Healthcare, Zurich, Switzerland, ⁷Swiss Center for Musculoskeletal Imaging (SCMI), Balgrist Campus, Zurich, Switzerland, ⁸Advanced Clinical Imaging Technology (ACIT), Siemens Healthcare, Bern, Switzerland, ⁹Translational Imaging Center, Sitem-Insel, Bern, Switzerland, ¹⁰Departments of Radiology and Biomedical Research, University of Bern, Bern, Switzerland

A reliable and non-invasive measurement of myelin content in the brain is of high importance for neurodegenerative diseases such as multiple sclerosis. To this end, various methods have been developed over the past years with different advantages and shortcomings. In this work, six widely used methods are compared and tested for reproducibility: (i) longitudinal relaxation rate, (ii) magnetization transfer ratio, (iii) macromolecular proton fraction, (iv) inhomogeneous magnetization transfer saturation, (v) myelin water fraction, and (vi) inversion recovery at ultra-short echo time. This comparison may facilitate an informed decision on which myelin imaging techniques should be used in future studies.

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