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Abstract #0098

Combined blood flow and CO2-mediated effects underlie the tissue-specific response to hypercapnia: Insight from 7T MR-based imaging

Allen A Champagne1,2 and Alex A Bhogal3
1School of Medicine, Queen's University, Kingston, ON, Canada, 2Center for Neuroscience Studies, Queen's University, Kingston, ON, Canada, 3Radiology, University Medical Center Utrecht, Utrecht, Netherlands

Cerebrovascular reactivity (CVR) mapping is finding increasing clinical applications as a non-invasive probe for vascular health. Untangling physiological factors driving differences in temporal delays within the tissue-specific CVR response can help better understand the pathophysiological mechanisms associated with vascular impairments. Here, we combine hypercapnic and hyperoxic respiratory challenges with high resolution 7T MR-based imaging to gather insight about differences in the temporal response to CVR between grey- and white-matter tissues. Our findings support the hypothesis that differences in the physiological response to hypercapnia may be determined by compounding effects related to CO2 sensitivity and blood flow (re)distribution.

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