Abstract #0098

Combined blood flow and CO2-mediated effects underlie the tissue-specific response to hypercapnia: Insight from 7T MR-based imaging

Allen A Champagne^1,2 and Alex A Bhogal³

¹School of Medicine, Queen's University, Kingston, ON, Canada, ²Center for Neuroscience Studies, Queen's University, Kingston, ON, Canada, ³Radiology, University Medical Center Utrecht, Utrecht, Netherlands

Cerebrovascular reactivity (CVR) mapping is finding increasing clinical applications as a non-invasive probe for vascular health. Untangling physiological factors driving differences in temporal delays within the tissue-specific CVR response can help better understand the pathophysiological mechanisms associated with vascular impairments. Here, we combine hypercapnic and hyperoxic respiratory challenges with high resolution 7T MR-based imaging to gather insight about differences in the temporal response to CVR between grey- and white-matter tissues. Our findings support the hypothesis that differences in the physiological response to hypercapnia may be determined by compounding effects related to CO₂ sensitivity and blood flow (re)distribution.

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