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Abstract #0099

7T QSM guided Histologically Consistent Thalamic Sub-nucleus Parcellation in 3T QSM Atlas Space

Weimin Zhang1, Chenyu He1, Xiaojun Guan2, Xiaojun Xu2, Hongjiang Wei3, and Yuyao Zhang1,4,5
1School of Information Science and Technology, ShanghaiTech University, Shanghai, China, 2Department of Radiology, The Second Affiliated Hospital, Zhejiang, China, 3Institute for Medical Imaging Technology, School of Biomedical Engineering, Shanghai, China, 4Shanghai Engineering Research Center of Intelligent Vision and Imaging, ShanghaiTech University, Shanghai, China, 5iHuman Institute, ShanghaiTech University, Shanghai, China

The thalamus is a relay station that routed and modulated brain signals from the deep gray-matter to the cortex. It can be divided into sub-nuclei that are highly related to various neurological disorders. However, those sub-nuclei are indistinguishable in standard T1 or T2 weighted MRI. We present a multi-atlas thalamic sub-nucleus parcellation framework guided by 7T QSM image, which provides histologically consistent contrast in thalamic sub-nuclei. Combining with a set of 3T QSM images, the thalamic parcellation in 7T image space is transferred into the 3T atlas space as a 64 sub-nucleus parcellation map.

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