Abstract #0099

7T QSM guided Histologically Consistent Thalamic Sub-nucleus Parcellation in 3T QSM Atlas Space

Weimin Zhang¹, Chenyu He¹, Xiaojun Guan², Xiaojun Xu², Hongjiang Wei³, and Yuyao Zhang^1,4,5

¹School of Information Science and Technology, ShanghaiTech University, Shanghai, China, ²Department of Radiology, The Second Affiliated Hospital, Zhejiang, China, ³Institute for Medical Imaging Technology, School of Biomedical Engineering, Shanghai, China, ⁴Shanghai Engineering Research Center of Intelligent Vision and Imaging, ShanghaiTech University, Shanghai, China, ⁵iHuman Institute, ShanghaiTech University, Shanghai, China

The thalamus is a relay station that routed and modulated brain signals from the deep gray-matter to the cortex. It can be divided into sub-nuclei that are highly related to various neurological disorders. However, those sub-nuclei are indistinguishable in standard T1 or T2 weighted MRI. We present a multi-atlas thalamic sub-nucleus parcellation framework guided by 7T QSM image, which provides histologically consistent contrast in thalamic sub-nuclei. Combining with a set of 3T QSM images, the thalamic parcellation in 7T image space is transferred into the 3T atlas space as a 64 sub-nucleus parcellation map.

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