We propose an integrated and efficient solution to clinical whole-brain MRI in a single 10min sequence, producing co-registered, quantitative PD, T1, T2, T1ρ, T2*, QSM, and ΔB0 information plus clinically adopted, synthetic contrast-weighted images including PDw, T1w, T2w, T2*w, FLAIR, SWI, true-SWI, mIP, and true-SWI mIP simultaneously. Quantitative maps and contrast-weighted images are generated with good image quality and contrasts. Quantitative measurements agree with literature values. This method has the clinical potential for comprehensive risk assessment and disease evaluation, combining early detection, diagnosis, tissue characterization, and treatment monitoring of various brain diseases.
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