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Abstract #0104

High-Fidelity Diffusion Tensor Imaging of the Thoracic Spinal Cord Using Point-Spread-Function Encoded EPI (PSF-EPI)

Sisi Li1, Yishi Wang2, Zhangxuan Hu3, Zhe Zhang4, Bing Wu3, and Hua Guo1
1Center for Biomedical Imaging Research, Beijing, China, 2Philips Healthcare, Beijing, China, 3GE Healthcare, MR Research China, Beijing, China, 4China National Clinical Research Center for Neurological Diseases, Beijing Tiantan Hospital, Capital Medical University, Beijing, China

Diffusion tensor imaging (DTI) holds great potential to aid the diagnosis of spinal cord pathologies. Single shot EPI (SS-EPI) is mostly implemented for DTI but is significantly limited in clinics by susceptibility inhomogeneity-induced distortions. This is especially problematic in the thoracic region for increased inhomogeneities near lungs. To solve this problem, multi-shot EPI and reduced-FOV methods have been proposed. However, these methods cannot remove distortions completely. In this study, we achieved high-fidelity DTI of the thoracic spinal cord using a distortion-free MS-EPI technique, Point-Spread-Function Encoded EPI (PSF-EPI). Both the efficacy of PSF-EPI in distortion correction and quantitative reproducibility were evaluated.

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