Strong spherical diffusion encoding enables visualization of isotropically restricted regions in the human brain, believed to resemble densely packed cells. As this forces imaging in a low SNR regime, visualization has been limited to a low resolution to avoid deleterious signal bias caused by the noise floor. In this work, we propose a novel method based on super-resolution reconstruction to enable high-resolution visualization of isotropically restricted diffusion in human brain in vivo. We show that our method is superior over conventional methods with acquisition times that are compatible with clinical routine.
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