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Abstract #0109

High-resolution visualization of isotropically restricted diffusion in brain by strong spherical dMRI and super-resolution reconstruction

Geraline Vis1, Markus Nilsson1, and Filip Szczepankiewicz1
1Diagnostic Radiology, Clinical Sciences Lund, Lund University, Lund, Sweden

Strong spherical diffusion encoding enables visualization of isotropically restricted regions in the human brain, believed to resemble densely packed cells. As this forces imaging in a low SNR regime, visualization has been limited to a low resolution to avoid deleterious signal bias caused by the noise floor. In this work, we propose a novel method based on super-resolution reconstruction to enable high-resolution visualization of isotropically restricted diffusion in human brain in vivo. We show that our method is superior over conventional methods with acquisition times that are compatible with clinical routine.

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