Abstract #0113

Estimation of fractional myocardial blood volume and water exchange using ferumoxytol-enhanced MRI

Caroline Colbert¹, Michael A. Thomas², Ran Yan³, Aleksandra Radjenovic⁴, J. Paul Finn^1,5, Peng Hu^1,3,5, and Kim-Lien Nguyen^1,2,5

¹Physics and Biology in Medicine Graduate Program, David Geffen School of Medicine at UCLA, Los Angeles, CA, United States, ²Division of Cardiology, UCLA David Geffen School of Medicine, Los Angeles, CA, United States, ³Department of Radiology, UCLA David Geffen School of Medicine, Los Angeles, CA, United States, ⁴Institute of Cardiovascular & Medical Sciences, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom, ⁵Diagnostic Cardiovascular Imaging Laboratory, Department of Radiological Sciences, UCLA David Geffen School of Medicine, Los Angeles, CA, United States

We optimized and tested a two-compartment water exchange model for fractional myocardial blood volume (fMBV) quantification. Nine healthy swine and one swine model with single-vessel coronary stenosis underwent MOLLI T1 imaging at 3.0 T following multiple individual ferumoxytol infusions. Healthy normal swine showed a mean mid-ventricular fMBV of 7.2 ± 1.4% and water exchange rate of 11.3 ± 5.1 s^-1. In one swine model with artificially‑induced single-vessel coronary stenosis, quantitative pixel-wise fMBV showed regional differences in hypoperfused relative to perfused regions. This study demonstrates the feasibility of fMBV estimation using multi-dose ferumoxytol‑enhanced MRI with a two-compartment water exchange model.

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