Abstract #0114

Brain oxygen extraction is differentially altered by Alzheimer’s and vascular diseases

Dengrong Jiang^1,2, Zixuan Lin^1,2, Peiying Liu¹, Sandeepa Sur¹, Cuimei Xu¹, Kaisha Hazel¹, George Pottanat¹, Jacqueline Darrow³, Jay J. Pillai^1,4, Sevil Yasar⁵, Paul Rosenberg⁶, Abhay Moghekar³, Marilyn Albert³, and Hanzhang Lu^1,2,7

¹The Russell H. Morgan Department of Radiology & Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD, United States, ²Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, MD, United States, ³Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, United States, ⁴Department of Neurosurgery, Johns Hopkins University School of Medicine, Baltimore, MD, United States, ⁵Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, United States, ⁶Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, United States, ⁷F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Research Institute, Baltimore, MD, United States

Alzheimer’s disease, vascular cognitive impairment and their concurrence represent the most common types of cognitive dysfunction. There exists a considerable overlap in their clinical symptoms and neuroimaging features, and we still lack effective tools for their differential diagnosis. This work demonstrated that cerebral oxygen-extraction-fraction (OEF) was differentially affected by Alzheimer’s (decrease OEF) and vascular (increase OEF) pathology. In individuals with low vascular risks, lower OEF was associated with worse cognitive performance and greater amyloid burden. In impaired patients, higher OEF was associated with great vascular risk factors. These findings suggest OEF can be useful in etiology-based diagnosis of cognitive impairment.

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