Abstract #0118

Five-Dimensional Quantitative Low-Dose Multitasking Dynamic Contrast- Enhanced MRI (LD-MT-DCE): Preliminary Study on Breast Cancer

Nan Wang^1,2, Yibin Xie¹, Zhaoyang Fan^1,2, Sen Ma^1,2, Rola Saouaf³, Yu Guo^1,4, Stephen L. Shiao^5,6, Anthony G. Christodoulou^1,2, and Debiao Li^1,2

¹Biomedical Imaging Research Institute, Cedars Sinai Medical Center, Los Angeles, CA, United States, ²Department of Bioengineering, University of California, Los Angeles, Los Angeles, CA, United States, ³Department of Imaging, Cedars Sinai Medical Center, Los Angeles, CA, United States, ⁴Department of Radiology, Tianjin First Central Hospital, Tianjin, China, ⁵Department of Radiation Oncology, Cedars-Sinai Medical Center, Los Angeles, CA, United States, ⁶Biomedical Sciences, Division of Immunology, Cedars-Sinai Medical Center, Los Angeles, CA, United States

DCE MRI is an important technique for diagnosing breast cancer, but continues to face technical challenges and gadolinium deposition concerns. In this work, we proposed a low-dose Multitasking DCE (LD-MT-DCE) technique, enabling dynamic-T1-mapping based quantitative characterization of tumor blood flow and vascular properties with whole-breast coverage, a spatial resolution of 0.9×0.9×1.1mm³, and a temporal resolution of 1.4 s using only 20% gadolinium dose. An in vivo study showed excellent image quality and repeatability (ICC≥0.99) for LD-MT-DCE and consistent diagnosis to standard-dose clinical DCE. The kinetic parameters showed significant differences between normal breast tissue, and benign and malignant tumors.

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