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Abstract #0118

Five-Dimensional Quantitative Low-Dose Multitasking Dynamic Contrast- Enhanced MRI (LD-MT-DCE): Preliminary Study on Breast Cancer

Nan Wang1,2, Yibin Xie1, Zhaoyang Fan1,2, Sen Ma1,2, Rola Saouaf3, Yu Guo1,4, Stephen L. Shiao5,6, Anthony G. Christodoulou1,2, and Debiao Li1,2
1Biomedical Imaging Research Institute, Cedars Sinai Medical Center, Los Angeles, CA, United States, 2Department of Bioengineering, University of California, Los Angeles, Los Angeles, CA, United States, 3Department of Imaging, Cedars Sinai Medical Center, Los Angeles, CA, United States, 4Department of Radiology, Tianjin First Central Hospital, Tianjin, China, 5Department of Radiation Oncology, Cedars-Sinai Medical Center, Los Angeles, CA, United States, 6Biomedical Sciences, Division of Immunology, Cedars-Sinai Medical Center, Los Angeles, CA, United States

DCE MRI is an important technique for diagnosing breast cancer, but continues to face technical challenges and gadolinium deposition concerns. In this work, we proposed a low-dose Multitasking DCE (LD-MT-DCE) technique, enabling dynamic-T1-mapping based quantitative characterization of tumor blood flow and vascular properties with whole-breast coverage, a spatial resolution of 0.9×0.9×1.1mm3, and a temporal resolution of 1.4 s using only 20% gadolinium dose. An in vivo study showed excellent image quality and repeatability (ICC≥0.99) for LD-MT-DCE and consistent diagnosis to standard-dose clinical DCE. The kinetic parameters showed significant differences between normal breast tissue, and benign and malignant tumors.

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