Abstract #0142

Ultrafast DCE MRI for post-NST evaluation of breast cancer

Maya Honda¹, Masako Kataoka¹, Rie Ota¹, Mami Iima^1,2, Akane Ohashi³, Kanae Kawai Miyake¹, Marcel Dominik Nickel⁴, Yosuke Yamada⁵, Masakazu Toi⁶, and Yuji Nakamoto¹

¹Graduate School of Medicine, Kyoto University, Kyoto, Japan, ²Institute for Advancement of Clinical and Translational Science (iACT), Kyoto University Hospital, Kyoto, Japan, ³Department of Radiology, National Hospital Organization Kyoto Medical Center, Kyoto, Japan, ⁴MR Application Predevelopment, Siemens Healthcare GmbH, Erlangen, Germany, ⁵Department of Diagnostic Pathology, Kyoto University Hospital, Kyoto, Japan, ⁶Department of breast surgery, Graduate School of Medicine, Kyoto University, Kyoto, Japan

The study evaluated the accuracy for predicting pathologic complete response (pCR) after neo-adjuvant systemic therapy (NST) using ultrafast dynamic contrast-enhanced (UF-DCE) MRI. The receiver operating characteristics (ROC) analysis for the presence of residual lesion revealed higher diagnostic performance of UF-DCE MRI compared with conventional dynamic contrast-enhanced (DCE) MRI overall and in the group of triple negative subtype. The deviation from pathology was smaller for UF-DCE MRI derived sizes compared to conventional DCE MRI overall and in luminal group. UF-DCE MRI potentially assesses the post-NAC status in breast cancer patients accurately in a shorter acquisition time.

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