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Abstract #0142

Ultrafast DCE MRI for post-NST evaluation of breast cancer

Maya Honda1, Masako Kataoka1, Rie Ota1, Mami Iima1,2, Akane Ohashi3, Kanae Kawai Miyake1, Marcel Dominik Nickel4, Yosuke Yamada5, Masakazu Toi6, and Yuji Nakamoto1
1Graduate School of Medicine, Kyoto University, Kyoto, Japan, 2Institute for Advancement of Clinical and Translational Science (iACT), Kyoto University Hospital, Kyoto, Japan, 3Department of Radiology, National Hospital Organization Kyoto Medical Center, Kyoto, Japan, 4MR Application Predevelopment, Siemens Healthcare GmbH, Erlangen, Germany, 5Department of Diagnostic Pathology, Kyoto University Hospital, Kyoto, Japan, 6Department of breast surgery, Graduate School of Medicine, Kyoto University, Kyoto, Japan

The study evaluated the accuracy for predicting pathologic complete response (pCR) after neo-adjuvant systemic therapy (NST) using ultrafast dynamic contrast-enhanced (UF-DCE) MRI. The receiver operating characteristics (ROC) analysis for the presence of residual lesion revealed higher diagnostic performance of UF-DCE MRI compared with conventional dynamic contrast-enhanced (DCE) MRI overall and in the group of triple negative subtype. The deviation from pathology was smaller for UF-DCE MRI derived sizes compared to conventional DCE MRI overall and in luminal group. UF-DCE MRI potentially assesses the post-NAC status in breast cancer patients accurately in a shorter acquisition time.

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