The compartmental origin of glucoCEST signal is still an ongoing debate. To address this crucial question, we proposed in this study to intravenously inject natural D-glucose and several metabolizable and non-metabolizable glucose analogues to compare their relative glucoCEST signal kinetics. The accurate measurements of glucoCEST signal kinetics provided deeper insights into the origin of glucoCEST signal and constitute a major step toward quantitative measurement of glucose metabolism using CEST imaging method. This could provide a new non-invasive tool to study brain energy metabolism defects observed in numerous neurodegenerative disorders.
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