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Abstract #0146

Motion correction for 3D CEST imaging without direct water saturation artefacts

Johannes Breitling1, Andreas Korzowski1, Neele Kempa1, Philip S. Boyd1, Mark E. Ladd1, Peter Bachert1, and Steffen Goerke1
1Division of Medical Physics in Radiology, German Cancer Research Center (DKFZ), Heidelberg, Germany

In CEST-MRI, motion correction is compromised by the drastically changing image contrast at different frequency offsets and particularly at the direct water saturation. In this study, a simple extension for conventional image registration algorithms is proposed, enabling a robust and accurate motion correction of CEST-MRI data. Performance of different approaches was investigated using a ground truth dataset, generated from repeated 3D in vivo measurements at 3 T, corrupted with realistic random rigid motion patterns and noise. In comparison to the conventional image registration and a cutting-edge algorithm specifically developed for CEST-MRI, the proposed method achieved more accurate and robust results.

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