Abstract #0147

Diffusion-weighted Chemical Exchange Saturation Transfer Imaging at 7T Human MRI

Yujin Jung¹, Jaeseok Park², Seong-Gi Kim², and Sung-Hong Park¹

¹Department of Bio and Brain engineering, Korea Advanced Institute of Science and Technology, Daejeon, Korea, Republic of, ²Department of Global Biomedical Engineering, Sungkyunkwan University, Suwon, Korea, Republic of

CEST is a useful method to diagnose tumor or stroke, but lacks physical information such as compartments with different diffusivities. In this study, we developed a new diffusion-weighted steady-state CEST sequence using 3D EPI at 7T. The technique was tested in phantom and human brain, and the preliminary CEST-weighted apparent diffusion coefficient maps provided both CEST and diffusion information. Further study is required to clearly understand the signal source and the potential as a new biomarker.

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