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Abstract #0148

Deep Learning Enables A Half Z-spectrum Sampling-based B0 Inhomogeneity Correction for CEST MRI

Yiran Li1, Danfeng Xie1, Dushyant Kumar2, Abigail Cember2, Ravi Prakash Reddy Nanga2, Hari Hariharan2, John A. Detre3, Ravinder Reddy2, and Ze Wang1
1Department of Diagnostic Radiology and Nuclear Medicine, University of Maryland School of Medicine, Baltimore, MD, United States, 2Department of Radiology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, United States, 3Department of Neurology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, United States

This study presents a DL based framework for correcting B0 inhomogeneity for GluCEST imaging using fewer acquisitions. Based on 3 or 5 positive offset CEST images, the proposed method can save >80% of CEST imaging acquisition time as compared to current 26 pairs of double site z-spectrum irradiations based protocol. This approach can be applied to other CEST imaging as well.

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