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Abstract #0152

Motion corrected magnetization transfer-mediated fingerprinting (MT-MRF) using DISORDER.

Daniel J. West1, Lucilio Cordero-Grande1,2,3, Rui P. A. G. Teixeira1,2, Giulio Ferrazzi4, Joseph V. Hajnal1,2, and Shaihan J. Malik1,2
1Biomedical Engineering and Imaging Sciences, King's College London, London, United Kingdom, 2Centre for the Developing Brain, King's College London, London, United Kingdom, 3Biomedical Image Technologies, ETSI Telecomunicación, Universidad Politécnica de Madrid & CIBER-BNN, Madrid, Spain, 4IRCCS San Camilo Hospital, Venice, Italy

ihMT is a promising approach for myelin imaging due to its specificity to substances with non-zero dipolar order. However, tissue model quantification requires high resolution acquisitions in excess of twenty minutes in length and so necessitates the use of motion correction methods to prevent artefacts. In this work we combine our recent MT-mediated MRF sequence with the DISORDER retrospective motion correction method. This new framework can acquire and reconstruct high resolution motion-compensated 3D time-resolved data from fingerprinting sequences. Semi‑quantitative MT and ihMT ratio maps as well as quantitative maps of tissue parameters can be obtained from the resulting images.

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