Abstract #0153

Formalism of the T1Ρ* relaxation pathway: Correction of quantification errors for rapid myocardial T1Ρ mapping in mice

Maximilian Gram^1,2, Daniel Gensler^1,3, Patrick Winter^1,2, Fabian Gutjahr^2,3, Michael Seethaler^2,3, Peter Michael Jakob², and Peter Nordbeck^1,3

¹Department of Internal Medicine I, University Hospital Würzburg, Würzburg, Germany, ²Experimental Physics 5, University of Würzburg, Würzburg, Germany, ³Comprehensive Heart Failure Center (CHFC), University Hospital Würzburg, Würzburg, Germany

The rapid quantification of T_1ρ using fast gradient echo sequences for data acquisition leads to a contamination of the T_1ρ relaxation pathway. Analogous to the T₁^* relaxation occurring in snapshot flash sequences, a relaxation pathway T_1ρ^* is effectively observed. As a consequence, quantification errors can arise depending on T₁ and the sequence parameters used for imaging. In this work we introduce a formalism for the description of T_1ρ^* and present a method that can be applied for the subsequent correction of study results in the field of cardiac MRI.

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