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Abstract #0156

Mapping functional connectivity of thalamus subdivisions in obsessive-compulsive disorder

Lingxiao Cao1, Hailong Li1, Jing Liu1, Xue Li2, Suming Zhang1, Xinyu Hu1, Qiyong Gong1, and Xiaoqi Huang1
1Huaxi MR Research Center (HMRRC), Functional and molecular imaging Key Laboratory of Sichuan Province, Department of Radiology, West China Hospital, Sichuan University, Chengdu, China, 2Sichuan University, Chengdu, China

Using connectivity-based parcellation technique, we segmented thalamus into two distinct subdivisions comprising superior thalamus and inferior thalamus based on their similarity in resting-state functional connectivity properties. We then compared the functional connectivity profiles of each thalamic subdivisions between the obsessive-compulsive disorder (OCD) patients and healthy control (HC), and revealed the disturbances of the superior/inferior thalamo-cortical and inferior thalamo-cerebellar circuitry in OCD patients. These findings suggested that thalamus subdivisions play different role in motor, cognitive, affective processes in OCD, which may underlie the pathophysiology of the disorder.

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