Abstract #0157

Abnormal cerebrovascular reactivity in human immunodeficiency virus-infected patients with or without smoking: a resting-state fMRI study

Lincoln Kartchner¹, Linda Chang², Thomas Ernst², Huajun Liang², Yuangi Shang², and Peiying Liu¹

¹Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, MD, United States, ²Department of Diagnostic Radiology and Nuclear Medicine, University of Maryland School of Medicine, Baltimore, MD, United States

Human immunodeficiency virus (HIV) infection is associated with neurodegeneration, but its effect on cerebrovascular function is not well understood. In a cohort of 160 participants, we investigated the effects of HIV and smoking on cerebrovascular reactivity (CVR) measured with standard resting-state blood oxygenation level dependent (BOLD)-fMRI. Across four participant groups (HIV+/HIV- x smokers/nonsmokers), both HIV-infection and smoking status altered CVR, but their effects were different across brain regions. Furthermore, lower nadir CD4 predicted lower thalamus CVR.

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