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Abstract #0158

Resting-State fMRI Frequency Change During Brain Aging

Xiaole Zhong1 and J. Jean Chen1,2
1Rotman Research Institute, Baycrest Health Sciences, Toronto, ON, Canada, 2Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada

Frequency features of the resting-state functional magnetic resonance imaging (rs-fMRI) signal can be crucial metrics that reveal patterns of brain aging. However, how the frequency shift during brain aging is still unclear. In this study, we examined the peak frequency and standard deviation of the rs-fMRI signal in healthy aging adults, divided into (0-0.1 Hz) and (0.1-0.3 Hz) bands. We found that in older adults, rs-fMRI fluctuation amplitude is lower but fluctuation frequency is higher in older adults, and these effects depend on the fMRI frequency range.

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