Abstract #0159

The effect of scan length on reliability of resting-state fMRI in patients with drug-resistant epilepsy (DRE) in awake and under anesthesia

Faezeh Vedaei^1,2, Mahdi Alizadeh¹, Sara Thalheimer¹, Victor Romo³, Feroze Mohamed⁴, and Chengyuan Wu¹

¹Department of Neurosurgery, Thomas Jefferson University, Philadelphia, PA, United States, ²Department of Bioengineering, Temple University, Philadelphia, PA, United States, ³Department of Anesthesiology, Thomas Jefferson University, Philadelphia, PA, United States, ⁴Department of Radiology, Thomas Jefferson University, Philadelphia, PA, United States

Resting-state fMRI suffers from poor test-retest reliability because of between-subject and within-subject variability. Scan duration is one the main factors affects the reliability of rs-fMRI studies. We showed that under anesthesia, the time needed to optimize ICC of rs-fMRI metrics including ALFF, fALFF, functional connectivity, and ReHo is lower compare with awake state. The optimum scan duration that satisfies good reliability is 14-20 min and 8-17 min in awake and under anesthesia, respectively. Also, variability of ICCs is lower under anesthesia than in awake.

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