The T2DM patients with cognitive impairment showed altered global efficiency(Eg), local efficiency(Eloc), clustering-coefficient(Cp), shortest-path-length(Lp) as well as nodal efficiencies in both structural and functional networks, compared to those with normal cognition and healthy controls. Some network metrics were correlated with neuropsychological assessments and disease severity. The disrupted topological organization of structural and functional connectomes (measured by Eg, Eloc, Cp and Lp) were found in T2DM with cognitive impairment, while these topological properties in T2DM with normal cognition were preserved equally to controls. The structural and functional connectomes research shows potential feasibility in characterizing intrinsic alterations of diabetic encephalopathy.
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