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Abstract #0161

Neuroimaging and obesity in adults with pre-diabetes or diabetes: results from the UK Biobank

Christopher R. Kouyoumdjian1, Kayley Marchena2,3, Masud Hussain3, and Bradley J. MacIntosh2,3
1University of Toronto, Scarborough, ON, Canada, 2Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada, 3Sunnybrook Research Institute, Toronto, ON, Canada

Glycated haemoglobin and body mass index (BMI) are implicated in neurodegeneration and diabetes. Diabetes-related changes in T2* estimates and fractional amplitude of low frequency fluctuations (fALFFs) are less understood. We investigated these neuroimaging estimates within the thalamic nuclei, hippocampi, and caudate nuclei of the UK Biobank-derived pre-diabetes and diabetes adult groups. Multiple regression analyses elucidated BMI as the robust predictor of hippocampal T2* estimates in both subgroups. These metrics extracted from two pulse sequences were helpful in understanding the brain and BMI associations, which is important in the assessment of diabetes and pre-diabetes as a risk factor for neurodegenerative disorders.

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