Glycated haemoglobin and body mass index (BMI) are implicated in neurodegeneration and diabetes. Diabetes-related changes in T2* estimates and fractional amplitude of low frequency fluctuations (fALFFs) are less understood. We investigated these neuroimaging estimates within the thalamic nuclei, hippocampi, and caudate nuclei of the UK Biobank-derived pre-diabetes and diabetes adult groups. Multiple regression analyses elucidated BMI as the robust predictor of hippocampal T2* estimates in both subgroups. These metrics extracted from two pulse sequences were helpful in understanding the brain and BMI associations, which is important in the assessment of diabetes and pre-diabetes as a risk factor for neurodegenerative disorders.
How to access this content:
For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.
After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.
After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.
Keywords