Abstract #0162

Altered brain functional network dynamics in obsessive-compulsive disorder

Lekai Luo¹, Qian Li¹, Wanfang You¹, Yuxia Wang¹, Yanchun Yang², Qiyong Gong¹, and Fei Li¹

¹Huaxi MR Research Centre (HMRRC), Department of Radiology, West China Hospital of Sichuan University, Chengdu, China, ²Psychiatry, West China Hospital of Sichuan University, Chengdu, China

Dynamic functional connectivity (dFC) and dynamic topological analyses were used to investigate the whole brain resting-state dynamic property abnormalities in patients with obsessive-compulsive disorder (OCD). Our results provide evidence of clinically relevant aberrant dynamic brain activity in OCD. Increased functional segregation among networks and impaired functional flexibility in connections among brain regions in default mode network (DMN) and salience network (SAN) may play important roles in the neuropathology of OCD.

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