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Abstract #0162

Altered brain functional network dynamics in obsessive-compulsive disorder

Lekai Luo1, Qian Li1, Wanfang You1, Yuxia Wang1, Yanchun Yang2, Qiyong Gong1, and Fei Li1
1Huaxi MR Research Centre (HMRRC), Department of Radiology, West China Hospital of Sichuan University, Chengdu, China, 2Psychiatry, West China Hospital of Sichuan University, Chengdu, China

Dynamic functional connectivity (dFC) and dynamic topological analyses were used to investigate the whole brain resting-state dynamic property abnormalities in patients with obsessive-compulsive disorder (OCD). Our results provide evidence of clinically relevant aberrant dynamic brain activity in OCD. Increased functional segregation among networks and impaired functional flexibility in connections among brain regions in default mode network (DMN) and salience network (SAN) may play important roles in the neuropathology of OCD.

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