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Abstract #0164

Altered dynamic functional connectivity in subjects with cerebral glioma

Siqi Cai1,2, Zhifeng Shi3, Yuchao Liang4, Chunxiang Jiang1,2, Shihui Zhou1,2, and Lijuan Zhang*1
1Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China, 2University of Chinese Academy of Sciences, Beijing, China, 3Huashan Hospital of Fudan University, Shanghai, China, 4Neurosurgery, Beijing Tiantan Hospital of Capital Medical University, Beijing, China

This study investigated the impact of cerebral glioma on the dynamic properties of functional connectivity (dFC). Cerebral gliomas induce alteration in dFC featuring more frequent strengthened connectivity and state transition between strong and sparse functional connectivity, indicating an extensive disturbance of functional segregation. As alterations in the dFC were reported to be associated with the progression of brain diseases, dFC variation induced by glioma may entail additional information to interpret the clinical profiles that are not ascribed to the lesion topology and serve as a new biomarker for the tumor characterization of glioma.

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