Abstract #0165

Myelin Water Fraction Mapping in developing children using Magnetic Resonance Fingerprinting

Matteo Cencini^1,2, Marta Lancione^2,3, Laura Biagi^1,2, Jan W Kurzawski^1,2, Rosa Pasquariello¹, Graziella Donatelli^2,4, Claudia Dosi^1,5, Chiara Ticci^1,5, Roberta Battini^1,5, Guido Buonincontri^1,2, and Michela Tosetti^1,2

¹IRCCS Stella Maris, Pisa, Italy, ²Imago7 Foundation, Pisa, Italy, ³IMT School for Advanced Studies Lucca, Lucca, Italy, ⁴Neuroradiology Unit, Azienda Ospedaliero-Universitaria Pisana, Pisa, Italy, ⁵Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy

Magnetic Resonance Fingerprinting (MRF) has been used to obtain Myelin Water Fraction (MWF) estimates in a cohort of developing children by using a three-component signal model. Here, we used a recent approach in which we perform sub-voxel tissue characterization without assumptions on the number and properties of the model components. We then used this signal model to study the myelination process in the developing brain on a 2D MRF dataset. Finally, we measured MWF on a set of subjects acquired with 3D MRF scan and compared the results to the 2D experiment.

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