Abstract #0166

Simultaneous morphometry and relaxometry of the human brain using three-dimensional MR fingerprinting at 1.5 and 3T

Shohei Fujita^1,2, Matteo Cencini^3,4, Guido Buonincontri^3,4, Naoyuki Takei⁵, Rolf F. Schulte⁶, Wataru Uchida¹, Akifumi Hagiwara¹, Koji Kamagata¹, Osamu Abe², Michela Tosetti^3,4, and Shigeki Aoki¹

¹Department of Radiology, Juntendo University, Tokyo, Japan, ²Department of Radiology, The University of Tokyo, Tokyo, Japan, ³Imago7 Foundation, Pisa, Italy, ⁴IRCCS Stella Maris, Pisa, Italy, ⁵MR Applications and Workflow, GE Healthcare, Tokyo, Japan, ⁶GE Healthcare, Munich, Germany

Magnetic resonance fingerprinting (MRF) permits simultaneous acquisition of T1 and T2 maps perfectly aligned to the anatomy, allowing morphometry and relaxometry analysis of the brain in a single scan. Here, we examined the reproducibility and repeatability of simultaneous morphology and relaxometry of brain structures in healthy volunteers using three-dimensional MRF at multiple field strengths. Scan-rescan tests of three-dimensional MRF were performed at 1.5 and 3T. The local thickness, volume, T1, and T2 values were calculated for each representative neuroanatomical structure using automatic brain segmentation software. These results can help establish imaging biomarkers using MRF for clinical use.

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