Abstract #0198

Glutamatergic responses to a color-word Stroop task in first-episode schizophrenia: A 7-Tesla functional MRS study

Peter Jeon¹, Michael MacKinley², Kara Dempster³, Dickson Wong⁴, Lena Palaniyappan^1,2,5,6, and Jean Theberge^1,5,7

¹Medical Biophysics, Western University, London, ON, Canada, ²Neuroscience, Western University, London, ON, Canada, ³Psychiatry, Dalhousie University, Halifax, NS, Canada, ⁴Schulich School of Medicine and Dentistry, Western University, London, ON, Canada, ⁵Psychiatry, Western University, London, ON, Canada, ⁶Robarts Research Institute, London, ON, Canada, ⁷Lawson Health Research Institute, London, ON, Canada

Dynamic behaviour of neurometabolites require tools that are able to capture such temporal information. Functional MRS can track metabolite level changes in response to external stimuli, providing valuable observations for illnesses such as schizophrenia. This study employed a 7-Tesla fMRS technique to study the anterior cingulate cortex glutamate, glutamine, and glutathione dynamic behaviours in 38 first-episode schizophrenia and 27 healthy controls. In response to a color-word Stroop task, significant differences were observed in resting and dynamic glutathione levels, supporting abnormal neurometabolite behaviour or circuitry in the early stages of schizophrenia.

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