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Abstract #0198

Glutamatergic responses to a color-word Stroop task in first-episode schizophrenia: A 7-Tesla functional MRS study

Peter Jeon1, Michael MacKinley2, Kara Dempster3, Dickson Wong4, Lena Palaniyappan1,2,5,6, and Jean Theberge1,5,7
1Medical Biophysics, Western University, London, ON, Canada, 2Neuroscience, Western University, London, ON, Canada, 3Psychiatry, Dalhousie University, Halifax, NS, Canada, 4Schulich School of Medicine and Dentistry, Western University, London, ON, Canada, 5Psychiatry, Western University, London, ON, Canada, 6Robarts Research Institute, London, ON, Canada, 7Lawson Health Research Institute, London, ON, Canada

Dynamic behaviour of neurometabolites require tools that are able to capture such temporal information. Functional MRS can track metabolite level changes in response to external stimuli, providing valuable observations for illnesses such as schizophrenia. This study employed a 7-Tesla fMRS technique to study the anterior cingulate cortex glutamate, glutamine, and glutathione dynamic behaviours in 38 first-episode schizophrenia and 27 healthy controls. In response to a color-word Stroop task, significant differences were observed in resting and dynamic glutathione levels, supporting abnormal neurometabolite behaviour or circuitry in the early stages of schizophrenia.

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