Abstract #0199

Positive emotional training with real-time functional MRI amygdala neurofeedback increased hippocampal volume for PTSD

Masaya Misaki¹, Beni Mulyana^1,2, Vadim Zotev¹, Brent E Wurfel³, Frank Krueger⁴, Matthew Feldner⁵, and Jerzy Bodurka^1,6

¹Laureate Institute for Brain Research, Tulsa, OK, United States, ²Electrical and Computer Engineering, University of Oklahoma, Tulsa, OK, United States, ³Laureate Psychiatric Clinic and Hospital, Tulsa, OK, United States, ⁴Neuroscience Department, George Mason University, Fairfax, VA, United States, ⁵Department of Psychological Science, University of Arkansas, Fayetteville, AR, United States, ⁶Stephenson School of Biomedical Engineering, University of Oklahoma, Norman, OK, United States

While small hippocampal volume is a prevalent neurostructural abnormality in posttraumatic stress disorder (PTSD), whether hippocampal atrophy is a reversible alteration or a permanent trait is unclear. This study examined a volume change among hippocampal subfields due to positive emotion training with left amygdala (LA) fMRI neurofeedback (LA-NF) in PTSD participants. A significant volume increase was seen in the left CA1-head region after the training. This indicates that the small hippocampus in PTSD is a reversible alteration in a part of the subfields and that positive emotion training with LA-NF could induce a hippocampal volume recovery.

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