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Abstract #0199

Positive emotional training with real-time functional MRI amygdala neurofeedback increased hippocampal volume for PTSD

Masaya Misaki1, Beni Mulyana1,2, Vadim Zotev1, Brent E Wurfel3, Frank Krueger4, Matthew Feldner5, and Jerzy Bodurka1,6
1Laureate Institute for Brain Research, Tulsa, OK, United States, 2Electrical and Computer Engineering, University of Oklahoma, Tulsa, OK, United States, 3Laureate Psychiatric Clinic and Hospital, Tulsa, OK, United States, 4Neuroscience Department, George Mason University, Fairfax, VA, United States, 5Department of Psychological Science, University of Arkansas, Fayetteville, AR, United States, 6Stephenson School of Biomedical Engineering, University of Oklahoma, Norman, OK, United States

While small hippocampal volume is a prevalent neurostructural abnormality in posttraumatic stress disorder (PTSD), whether hippocampal atrophy is a reversible alteration or a permanent trait is unclear. This study examined a volume change among hippocampal subfields due to positive emotion training with left amygdala (LA) fMRI neurofeedback (LA-NF) in PTSD participants. A significant volume increase was seen in the left CA1-head region after the training. This indicates that the small hippocampus in PTSD is a reversible alteration in a part of the subfields and that positive emotion training with LA-NF could induce a hippocampal volume recovery.

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