Meeting Banner
Abstract #0201

Cerebral hemodynamic alterations associated with an in-scanner drug trial in adults with bipolar depression

William S.H. Kim1,2, Mikaela K. Dimick3,4, Danielle Omrin4, Beverley A. Orser4,5, Benjamin I. Goldstein4,6, and Bradley J. MacIntosh1,2
1Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada, 2Sunnybrook Research Institute, Toronto, ON, Canada, 3Department of Pharmacology and Toxicology, University of Toronto, Toronto, ON, Canada, 4Sunnybrook Health Sciences Centre, Toronto, ON, Canada, 5Department of Anesthesiology and Pain Medicine, University of Toronto, Toronto, ON, Canada, 6Department of Psychiatry, University of Toronto, Toronto, ON, Canada

Multiple post-label delay (multi-PLD) arterial spin labeling (ASL) magnetic resonance imaging is one approach to monitor cerebral hemodynamic drug responses. In addition to cerebral blood flow (CBF), it is possible to map arterial transit time (ATT) and arterial cerebral blood volume (aCBV). Here, we investigate multi-PLD ASL-derived CBF, ATT, and aCBV responses to a single treatment of either: 1) nitrous oxide or 2) midazolam among adults with treatment-resistant bipolar depression. Between baseline and post-treatment timepoints, we report treatment effects on CBF change in the temporal lobe and on ATT change in the frontal and parietal lobes.

This abstract and the presentation materials are available to members only; a login is required.

Join Here