Abstract #0201

Cerebral hemodynamic alterations associated with an in-scanner drug trial in adults with bipolar depression

William S.H. Kim^1,2, Mikaela K. Dimick^3,4, Danielle Omrin⁴, Beverley A. Orser^4,5, Benjamin I. Goldstein^4,6, and Bradley J. MacIntosh^1,2

¹Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada, ²Sunnybrook Research Institute, Toronto, ON, Canada, ³Department of Pharmacology and Toxicology, University of Toronto, Toronto, ON, Canada, ⁴Sunnybrook Health Sciences Centre, Toronto, ON, Canada, ⁵Department of Anesthesiology and Pain Medicine, University of Toronto, Toronto, ON, Canada, ⁶Department of Psychiatry, University of Toronto, Toronto, ON, Canada

Multiple post-label delay (multi-PLD) arterial spin labeling (ASL) magnetic resonance imaging is one approach to monitor cerebral hemodynamic drug responses. In addition to cerebral blood flow (CBF), it is possible to map arterial transit time (ATT) and arterial cerebral blood volume (aCBV). Here, we investigate multi-PLD ASL-derived CBF, ATT, and aCBV responses to a single treatment of either: 1) nitrous oxide or 2) midazolam among adults with treatment-resistant bipolar depression. Between baseline and post-treatment timepoints, we report treatment effects on CBF change in the temporal lobe and on ATT change in the frontal and parietal lobes.

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