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Abstract #0202

Disparate Cognitive Patterns Captured by Subcortical Profiles in Schizophrenia

Qiannan Zhao1, Hengyi Cao1,2,3, Yuan Xiao1, Qiyong Gong1, and Su Lui1
1Huaxi MR Research Center (HMRRC), Department of Radiology, West China Hospital, Sichuan University, Chengdu, China, 2Division of Psychiatry Research, Zucker Hillside Hospital, Glen Oaks, NY, United States, 3Center for Psychiatric Neuroscience, Feinstein Institute for Medical Research, Manhasset, NY, United States

Subcortical morphological abnormalities are associated with cognitive impairment in schizophrenia. We hypothesized that patients with different degree of cognitive impairment might be separated by subcortical morphological abnormalities. Here we identified two distinct clusters in patients with schizophrenia based on their regional subcortical volume. Different degree of regional subcortical volume, global brain volume and cognitive impairment were observed between two clusters of patients, with more severe cognitive impairment in the more severe morphological deficit cluster. These findings indicate critical relationships between subcortical structures and cognition in schizophrenia, and suggest that subcortical morphological abnormalities could help to capture cognitive profiles in schizophrenia.

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