Meeting Banner
Abstract #0203

Age-dependent effects of methylphenidate on emotional dysregulation: an RCT in stimulant treatment-naïve male ADHD patients

Antonia Kaiser1, Marco A. Bottelier1,2, Michelle M. Solleveld1, Hyke G.H. Tamminga1,3, Cheima Bouziane1, Ramon J.L. Lindauer4,5, Paul J. Lucassen6, Michiel B. de Ruiter1,7, Anouk Schrantee1, and Liesbeth Reneman1
1Department of Radiology and Nuclear Medicine, Amsterdam UMC, University of Amsterdam, Amsterdam, Netherlands, 2Child Study Center, Accare, Groningen, Netherlands, 3Dutch Autism and ADHD research center, University of Amsterdam, Amsterdam, Netherlands, 4Department of Child and Adolescent Psychiatry, Amsterdam UMC, University of Amsterdam, Amsterdam, Netherlands, 5De Bascule, Academic Centre for Child and Adolescent Psychiatry, Amsterdam, Netherlands, 6Brain Plasticity Group, Swammerdam Institute for Life Sciences, Center for Neuroscience, University of Amsterdam, Amsterdam, Netherlands, 7Division of Psychosocial Research and Epidemiology, Netherlands Cancer Institute, Amsterdam, Netherlands

Emotional dysregulation (ED) is an important outcome moderator of Attention-Deficit/Hyperactivity Disorder (ADHD). We previously found that acute administration of methylphenidate age-dependently modulated neural mechanisms underlying ED, i.e., amygdala reactivity, but effects of chronic methylphenidate administration remain unknown. Following randomization to 16 weeks of methylphenidate or placebo treatment, we here report a lasting improvement in ED, depressive and anxiety symptoms in ADHD children, whereas a transient improvement of ED and depressive symptoms occurred in adults, independent of treatment condition. Although depressive and anxiety symptoms at baseline negatively predicted ADHD symptom change in adults, age-dependent effects on amygdala reactivity were absent.

This abstract and the presentation materials are available to members only; a login is required.

Join Here