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Abstract #0205

Characterization of Apparent Exchange Rate in Human Brain White Matter

Zhaoqing Li1,2, Yi-Cheng Hsu3, and Ruiliang Bai1,2
1Interdisciplinary Institute of Neuroscience and Technology (ZIINT), School of Medicine, Zhejiang University, Hangzhou, China, HangZhou, China, 2College of Biomedical Engineering and Instrument Science, Zhejiang University, Hangzhou, China, HangZhou, China, 3MR Collaboration, Siemens Healthcare, Shanghai, China, ShangHai, China

Filter exchange imaging (FEXI) is a non-invasive method to measure water exchange among diffusion compartments by apparent exchange rate (AXR). However, in human white matter, it is still controversial whether the diffusion-encoding gradient direction will affect AXR measurement. In this study, we performed FEXI on human brain with 20 diffusion gradient directions to explore features of AXR in white matter. We found that AXR measured with diffusion direction perpendicular to fiber (~ 0.47 s-1) is significantly larger than that parallel to fiber (~ 0.15 s-1), suggesting FEXI at different directions might measure exchanges between different biological compartments in white matter.

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