Abstract #0206

Evaluation of White Matter Microstructure in an HIV Population at Risk of Cerebral Small Vessel Disease using Microscopic Fractional Anisotropy

Md Nasir Uddin¹, Abrar Faiyaz², and Giovanni Schifitto^1,3

¹Department of Neurology, University of Rochester, Rochester, NY, United States, ²Electrical & Computer Engineering, University of Rochester, Rochester, NY, United States, ³Imaging Sciences, University of Rochester, Rochester, NY, United States

White matter microstructural abnormalities are well documented in HIV-infected individuals. DTI derived fractional anisotropy (FA) is frequently used to assess the abnormalities but it has some limitations. In this work, we compared FA and microscopic fractional anisotropy (μFA) in an HIV cohort, and our results indicate that μFA seems to provide better sensitivity than the conventional FA for detecting white matter microstructure changes associated with HIV infection, especially in the areas with crossing fibers.

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