Resolving the underlying sources of kurtosis in biological systems is emerging as a promising strategy for non-invasive quantitative characterization of tissue microstructure. Recently, a novel framework termed Correlation Tensor Imaging (CTI), based on double-diffusion-encoding MRI, was shown to disentangle anisotropic, isotropic, and microscopic kurtosis sources in mouse brains. Here, we implemented CTI on a clinical 3T MRI system and scanned normal humans for the first time. The ensuing CTI-driven non-Gaussian inter/intra-compartmental estimates are promising and agree with expectations: positive intra-compartmental kurtosis for gray and white matter, larger for gray than white matter, and around zero for cerebrospinal fluid.
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