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Abstract #0207

Human brain in vivo correlation tensor MRI on a clinical 3T system

Lisa Novello1, Rafael Neto Henriques2, Andrada IanuĊŸ2, Thorsten Feiweier3, Noam Shemesh2, and Jorge Jovicich1
1Center for Mind/Brain Sciences - CIMeC, University of Trento, Rovereto, Italy, 2Champalimaud Research, Champalimaud Centre for the Unknown, Lisbon, Portugal, 3Siemens Healthcare GmbH, Erlangen, Germany

Resolving the underlying sources of kurtosis in biological systems is emerging as a promising strategy for non-invasive quantitative characterization of tissue microstructure. Recently, a novel framework termed Correlation Tensor Imaging (CTI), based on double-diffusion-encoding MRI, was shown to disentangle anisotropic, isotropic, and microscopic kurtosis sources in mouse brains. Here, we implemented CTI on a clinical 3T MRI system and scanned normal humans for the first time. The ensuing CTI-driven non-Gaussian inter/intra-compartmental estimates are promising and agree with expectations: positive intra-compartmental kurtosis for gray and white matter, larger for gray than white matter, and around zero for cerebrospinal fluid.

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