Abstract #0208

Feasibility of Filter-exchange Imaging (FEXI) in Measuring Different Exchange Processes in Human Brain

Zhaoqing Li^1,2, Chaoliang Sun^1,2, Yi-Cheng Hsu³, Hui Liang⁴, Peter Basser⁵, and Ruiliang Bai^1,2

¹Interdisciplinary Institute of Neuroscience and Technology (ZIINT), School of Medicine, Zhejiang University, Hangzhou, China, HangZhou, China, ²College of Biomedical Engineering and Instrument Science, Zhejiang University, Hangzhou, China, HangZhou, China, ³MR Collaboration, Siemens Healthcare, Shanghai, China, ShangHai, China, ⁴Department of Neurology, First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China, HangZhou, China, ⁵Section on Quantitative Imaging and Tissue Sciences, NICHD, National Institutes of Health, Bethesda, MD, USA, Bethesda, MD, United States

In this study, we aim to explore the feasibility of Filter-exchange imaging (FEXI) in measuring different water exchange processes in human brain by modulating the diffusion filter (b_f) and detection (b) blocks. We found the apparent exchange rate (AXR) estimated from a FEXI protocol with bf=250s/mm² are significantly larger than those with bf=900s/mm². Besides, the filter efficiency of FEXI with bf=250s/mm² shows a strong correlation with vascular density estimated as the fraction of water exhibiting intravoxel incoherent motion (IVIM). Collectively, our current results demonstrate that FEXI targeting the vascular water could help characterize the intra-to-extravascular water exchange process.

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