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Abstract #0208

Feasibility of Filter-exchange Imaging (FEXI) in Measuring Different Exchange Processes in Human Brain

Zhaoqing Li1,2, Chaoliang Sun1,2, Yi-Cheng Hsu3, Hui Liang4, Peter Basser5, and Ruiliang Bai1,2
1Interdisciplinary Institute of Neuroscience and Technology (ZIINT), School of Medicine, Zhejiang University, Hangzhou, China, HangZhou, China, 2College of Biomedical Engineering and Instrument Science, Zhejiang University, Hangzhou, China, HangZhou, China, 3MR Collaboration, Siemens Healthcare, Shanghai, China, ShangHai, China, 4Department of Neurology, First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China, HangZhou, China, 5Section on Quantitative Imaging and Tissue Sciences, NICHD, National Institutes of Health, Bethesda, MD, USA, Bethesda, MD, United States

In this study, we aim to explore the feasibility of Filter-exchange imaging (FEXI) in measuring different water exchange processes in human brain by modulating the diffusion filter (bf) and detection (b) blocks. We found the apparent exchange rate (AXR) estimated from a FEXI protocol with bf=250s/mm2 are significantly larger than those with bf=900s/mm2. Besides, the filter efficiency of FEXI with bf=250s/mm2 shows a strong correlation with vascular density estimated as the fraction of water exhibiting intravoxel incoherent motion (IVIM). Collectively, our current results demonstrate that FEXI targeting the vascular water could help characterize the intra-to-extravascular water exchange process.

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