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Abstract #0209

Is the inversion time important? A study of the reciprocal influence of inversion time and b-value on diffusion and longitudinal relaxation in MRI

Tomasz Pieciak1,2, Maryam Afzali3, Fabian Bogusz1, Dominika Ciupek1, Derek K. Jones3, and Marco Pizzolato4,5
1AGH University of Science and Technology, Kraków, Poland, 2LPI, ETSI Telecomunicación, Universidad de Valladolid, Valladolid, Spain, Valladolid, Spain, 3Cardiff University Brain Research Imaging Centre (CUBRIC), School of Psychology, Cardiff University, Cardiff, United Kingdom, 4Department of Applied Mathematics and Computer Science, Technical University of Denmark, Kongens Lyngby, Denmark, 5Signal Processing Lab (LTS5), École polytechnique fédérale de Lausanne (EPFL), Lausanne, Switzerland

The nervous tissue microstructure can be characterized by sensitizing the MRI signal to diffusion. The advent of multi-parametric sequences enabled the collection of diffusion data at different echo and inversion times. While the link between diffusion and transverse relaxation has undergone several investigations, in this work we characterize the relationship between the diffusion and longitudinal relaxation, and quantify the reciprocal influence of b-values and inversion time on the quantification of T1 and of diffusion metrics, interpreting our findings on in vivo data in the light of numerical simulations, and showing evidence that longitudinal relaxation locally modifies the diffusion contrast.

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