Abstract #0212

3t++ temporally consistent 3 tissue HARDI decomposition of neonatal brain tissue

Maximilian Pietsch^1,2, Daan Christiaens^2,3, Jana Hutter^2,4, Lucilio Cordero-Grande², Anthony N. Price^2,4, Emer Hughes², A. David Edwards², Joseph V. Hajnal^2,4, Serena J. Counsell², Jonathan O'Muircheartaigh^1,2,5,6, and J-Donald Tournier^2,4

¹Forensic & Neurodevelopmental Sciences, King's College London, London, United Kingdom, ²Centre for the Developing Brain, School of Biomedical Engineering and Imaging Sciences, King’s College London, Kings Health Partners, St. Thomas Hospital, London, SE1 7EH, UK, King's College London, London, United Kingdom, ³Department of Electrical Engineering (ESAT/PSI), KU Leuven, Leuven, Belgium, ⁴Biomedical Engineering Department, School of Biomedical Engineering and Imaging Sciences, King's College London, London, United Kingdom, ⁵Department of Perinatal Imaging & Health, School of Biomedical Engineering and Imaging Sciences, King's College London, London, United Kingdom, ⁶MRC Centre for Neurodevelopmental Disorders, King's College London, London, United Kingdom

We decompose neonatal HARDI signal into four components that together capture the orientation dependency and temporal dependency of signal in neonatal white and grey matter and CSF. We show that the voxel-wise volume fractions of the associated components exhibit distinct sigmoid-shaped time dependencies between 33 to 44 weeks gestational age and clearly delineate anatomical structures in developing white and grey matter, allowing detailed characterisation of microstructural properties of developing white and grey matter.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.