Abstract #0212

3t++ temporally consistent 3 tissue HARDI decomposition of neonatal brain tissue

Maximilian Pietsch^1,2, Daan Christiaens^2,3, Jana Hutter^2,4, Lucilio Cordero-Grande², Anthony N. Price^2,4, Emer Hughes², A. David Edwards², Joseph V. Hajnal^2,4, Serena J. Counsell², Jonathan O'Muircheartaigh^1,2,5,6, and J-Donald Tournier^2,4

¹Forensic & Neurodevelopmental Sciences, King's College London, London, United Kingdom, ²Centre for the Developing Brain, School of Biomedical Engineering and Imaging Sciences, King’s College London, Kings Health Partners, St. Thomas Hospital, London, SE1 7EH, UK, King's College London, London, United Kingdom, ³Department of Electrical Engineering (ESAT/PSI), KU Leuven, Leuven, Belgium, ⁴Biomedical Engineering Department, School of Biomedical Engineering and Imaging Sciences, King's College London, London, United Kingdom, ⁵Department of Perinatal Imaging & Health, School of Biomedical Engineering and Imaging Sciences, King's College London, London, United Kingdom, ⁶MRC Centre for Neurodevelopmental Disorders, King's College London, London, United Kingdom

We decompose neonatal HARDI signal into four components that together capture the orientation dependency and temporal dependency of signal in neonatal white and grey matter and CSF. We show that the voxel-wise volume fractions of the associated components exhibit distinct sigmoid-shaped time dependencies between 33 to 44 weeks gestational age and clearly delineate anatomical structures in developing white and grey matter, allowing detailed characterisation of microstructural properties of developing white and grey matter.

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