Concussion heterogeneity remains a major challenge for clinical and scientific research. Yet, most studies continue to employ group comparison approaches that assume consistent one-to-one relationships between brain structure and symptoms. To parse concussion heterogeneity, we employed a double-multivariate approach using diffusion MRI of children with histories of concussion. Multivariate white-matter structural features captured more information about symptoms than all individual features. Results also revealed how different white-matter abnormalities led to similar symptom profiles. Lastly, multivariate features significantly predicted adverse psychiatric outcomes. These results suggest that concussion heterogeneity arising from complex structure/symptom relationships can be well captured by our double-multivariate approach.
How to access this content:
For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.
After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.
After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.
Keywords